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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
39.7
Human Site:
S609
Identified Species:
54.58
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S609
A
I
I
Q
E
K
K
S
G
R
I
P
G
I
Y
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S609
A
I
I
Q
E
K
K
S
G
R
I
P
G
I
Y
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S608
A
V
I
Q
E
K
K
S
G
R
I
P
G
I
Y
Dog
Lupus familis
XP_535848
1288
147094
S609
A
I
I
Q
E
K
K
S
G
R
I
P
G
I
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S607
A
I
I
Q
E
K
K
S
G
R
I
P
G
I
Y
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
R564
I
Q
Y
I
K
E
Q
R
G
E
P
E
T
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
K453
K
M
T
V
W
E
K
K
M
S
K
I
P
T
P
Chicken
Gallus gallus
NP_989849
1274
145838
S580
A
L
L
E
Q
K
R
S
G
S
I
S
G
I
H
Frog
Xenopus laevis
P50532
1290
146971
S603
A
L
I
Q
Q
K
K
S
G
K
I
P
G
I
F
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
S608
T
L
M
Q
Q
K
R
S
G
K
I
P
G
I
L
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
T605
A
L
M
Q
Q
K
K
T
G
R
I
P
G
I
L
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
S864
A
K
L
H
D
E
I
S
Q
L
K
S
Q
A
E
Honey Bee
Apis mellifera
XP_396862
1282
148175
E545
N
L
M
R
E
K
S
E
G
R
I
P
G
I
F
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
A615
A
L
M
K
E
K
E
A
G
R
I
K
S
F
H
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
L608
A
L
M
E
Q
K
R
L
G
K
I
N
G
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
N551
A
V
L
R
A
K
E
N
N
Q
I
E
G
I
Y
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S682
A
L
S
R
L
Q
K
S
G
R
I
N
G
F
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
93.3
100
N.A.
100
6.6
N.A.
6.6
46.6
73.3
53.3
66.6
13.3
53.3
40
40
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
20
86.6
100
86.6
93.3
33.3
80
80
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
80
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
77
0
0
0
6
0
0
6
0
0
0
0
0
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
12
42
18
12
6
0
6
0
12
0
0
6
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
18
12
% F
% Gly:
0
0
0
0
0
0
0
0
83
0
0
0
77
0
0
% G
% His:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
18
% H
% Ile:
6
24
36
6
0
0
6
0
0
0
83
6
0
71
0
% I
% Lys:
6
6
0
6
6
77
53
6
0
18
12
6
0
0
0
% K
% Leu:
0
48
18
0
6
0
0
6
0
6
0
0
0
0
18
% L
% Met:
0
6
30
0
0
0
0
0
6
0
0
0
0
0
0
% M
% Asn:
6
0
0
0
0
0
0
6
6
0
0
12
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
6
53
6
0
6
% P
% Gln:
0
6
0
48
30
6
6
0
6
6
0
0
6
0
6
% Q
% Arg:
0
0
0
18
0
0
18
6
0
53
0
0
0
0
0
% R
% Ser:
0
0
6
0
0
0
6
59
0
12
0
12
6
0
0
% S
% Thr:
6
0
6
0
0
0
0
6
0
0
0
0
6
6
0
% T
% Val:
0
12
0
6
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
36
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _